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SARS-CoV-2 nsp13-IN-1

CAS No. 1005304-44-8

SARS-CoV-2 nsp13-IN-1( —— )

Catalog No. M35639 CAS No. 1005304-44-8

SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13), selectively inhibiting nsp13 ssDNA+ATPase with an IC50 of 6 μM, but not ssDNA-ATPase, and can be used to study COVID-19.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SARS-CoV-2 nsp13-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13), selectively inhibiting nsp13 ssDNA+ATPase with an IC50 of 6 μM, but not ssDNA-ATPase, and can be used to study COVID-19.
  • Description
    SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent nsp13 (non-structural protein 13) inhibitor. SARS-CoV-2 nsp13-IN-1 only inhibits nsp13 ssDNA+ ATPase, with an IC50 of 6 μM. SARS-CoV-2 nsp13-IN-1 does not inhibit ssDNA- ATPase. SARS-CoV-2 nsp13-IN-1 can be used for COVID-19 research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Immunology/Inflammation
  • Target
    Antiviral
  • Recptor
    Antiviral
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1005304-44-8
  • Formula Weight
    432.47
  • Molecular Formula
    C27H20N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 41.67 mg/mL (96.35 mM; Ultrasonic (<60°C)
  • SMILES
    CC1=NC2=C(C=CC=N2)C(=O)N1C1=CC=C(NC(=O)C2=CC=C(C=C2)C2=CC=CC=C2)C=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Yazdi AK, et al. Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. ACS Infect Dis. 2022 Jul 13.?
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